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239 Treatment with MAT2A inhibitors AG-24152 and AG-270 significantly reduces SAM levels, inhibits PRMT5 activity, and causes DNA damage and mitotic defects in tumor cells

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h , The mutational landscape and somatic mutation frequence (SMF) of each GGT gene was analyzed in 105,260 cancer patient samples across 226 non-redundant studies using the cBioPortal platform revealing a low mutation frequency (mean = 0.15%)